amyloidosis

What are the types?
The most common type of amyloidosis

Primary amyloidosis: Usually together with Multiple Myeloma and Monoclonal gammopathy of plasma cell disorders.

Secondary Amyloidosis: Rheumatoid arthritis, osteomyelitis; Malaria is with a variety of chronic inflammatory illnesses such as tuberculosis and leprosy.

Familial amyloidosis: Familial Mediterranean Fever (FMF) is associated with.

Hemodialysis amyloidosis: It is with renal hemodialysis.
Which acts on the system?
Kidney, Respiratory, Cardiovascular, Gastrointestinal, nerves, skin, is effective in the system.
What are the reasons?
Primary Amyloidosis
Diseases such as plasma, light chain (AL) is associated with excess immunoglobulin production.
Secondary Amyloidosis
in chronic inflammatory condition amyloid fibrillar proteins (A) is carried out in excess, and the degradation products of serum amyloid protein (SAA) phases occurs.
Familial amyloidosis
Familial Mediterranean fever, occur with excessive amyloid fibrillar amyloid protein made.
Hemodialysis Amyloidosis
Normally excreted by the kidneys, but can not consist of amyloid beta-2-microglobulin containing discarded by hemodialysis.
What are the pathological findings?
Demonstration of tissue Amyloid Deposits
Amyloid with Congo red staining, create green refraction under polarized light.
Electron Microscopy is subject to a definitive diagnosis.
What are the treatments?
Primary Amyloidosis
Treatment of the underlying plasma cell disease
Melphalan and prednisone are the drugs of choice for the plasma cell disease. Colchicine; It can slow amyloid deposition.
Secondary Amyloidosis
Underlying inflammatory disease treatment
Tacrine, mild to moderate dementia caused by Alzheimer's disease.
Familial amyloidosis
Colchicine 0.6 mg 2-3 times a day
Hemodialysis amyloidosis
Primary Amyloidosis
monitoring of monoclonal protein levels to assess response to treatment is required. monitoring of renal function to assess response to treatment.
Hemodialysis and Secondary Amyloidosis
Underlying followed up for assessment of renal function and disorders of control of the degree of affliction.