Conn Syndrome

What are the symptoms?
Usually asymptomatic.

Hypokalemia muscle weakness, muscle cramps, headache, palpitations, polydipsia, polyuria or

accompanied nocturia.

Moderate or severe hypertension (200/120 mmHg does not.)

Fundoskopi- Selim or Grade 1-2

tetani

hypokalemia

Metabolic alkalosis / Chvostek and Trousseau Symptoms (+)

Relative Hypernatremia

Impaired Glucose Tolerance

The incidence of renal cysts is high.

Headache

paresthesias

Cardiac Arrhythmias
What are the reasons?
Unilateral aldosterone-producing adenoma (APA), the most common (60%) is the result. (Conn syndrome) curing is achieved by unilateral adrenalectomy.

Idiopathic hyperaldosteronism (IHA) zona glomerulosa is bilateral hyperplasia is seen by 34%. Surgical treatment is not useful. Chronic medical therapy is preferred.
Maintenance and recommendations?
APA- unilateral unilateral adrenalectomy

Bilateral chronic medical treatment İHA-

Unilateral APA - hypokalemia; Spironolactone is controlled preoperatively.

Bilateral İHA- low-sodium diet, ideal body weight, smoking ban, potassium restriction, antihypertensive treatment (calcium channel blockers, ACE inhibitors, the thiazide diuretics)

Low Sodium Diets
What are the ways of treatment?
Spironolactone or amiloride

Antihypertensive drugs: calcium channel blocker, ACE inhibitor, low dose thiazide diuretics


ACE inhibitors; Renal failure, hyperkalemia, and I kullanılmaz.s kept under control during pregnancy gereklidir.lity potassium levels with diuretics, non steroidal anti-inflammatory may be interactions between drugs with diuretics and ACE inhibitors. Peripheral Alfa.1 Antagonists (Terazosin, Doxazosin) keeps under control hypertension.

Blood pressure monitoring,

Serum potassium tracking,

Postoperative 24-hour urinary aldosterone determination must be made.

AP surgical treatment of hypertension is improved by 70%. 1-4 months postoperative follow-up.