amyloidosis

Explanation The most common type of amyloidosis Primary amyloidosis: Usually together with Multiple Myeloma and Monoclonal gammopathy of plasma cell disorders. Secondary Amyloidosis: Rheumatoid arthritis, osteomyelitis; Malaria is with a variety of chronic inflammatory illnesses such as tuberculosis and leprosy. Familial amyloidosis: Familial Mediterranean Fever (FMF) is associated with. Hemodialysis amyloidosis: It is with renal hemodialysis. What are the symptoms? Which varies depending on what level of organ involvement. Weakness Weight Loss gastroparesis the pSEUDOOBSTRUCTION malabsorption Diarrhea macroglossia Peripheral Neuropathy Carpal Tunnel Syndrome ascites hepatomegaly dyspnea Interstitial Lung Disease Congestive Heart Failure arrhythmia Sudden death Hiler Adenopathy Mediastinal Adenopathy symmetric Polyarthritis Periarticular soft tissue swelling (consistency rubber) Papules on the skin (translucent, waxy) Purpura (periorbital) Edema Renal Failure nephrotic Syndrome Dementia (may play a role in the development of Alzheimer's Disease) What are the reasons? Primary Amyloidosis Diseases such as plasma, light chain (AL) is associated with excess immunoglobulin production. Secondary Amyloidosis in chronic inflammatory condition amyloid fibrillar proteins (A) is carried out in excess, and the degradation products of serum amyloid protein (SAA) phases occurs. Familial amyloidosis Familial Mediterranean fever, occur with excessive amyloid fibrillar amyloid protein made. Hemodialysis Amyloidosis Normally excreted by the kidneys, but can not consist of amyloid beta-2-microglobulin containing discarded by hemodialysis. What are the care and advice? If heart failure develops or serious complications such as renal failure are hospitalized. beta2-microglobulin should start to clear in Hemodialysis Peritoneal Dialysis amyloidosis. protein and salt are restricted in renal failure. In heart failure, salt restriction. What are the ways of treatment? Primary Amyloidosis Treatment of the underlying plasma cell disease Melphalan and prednisone are the drugs of choice for the plasma cell disease. Colchicine; It can slow amyloid deposition. Secondary Amyloidosis Underlying inflammatory disease treatment Tacrine, mild to moderate dementia caused by Alzheimer's disease. Familial amyloidosis Colchicine 0.6 mg 2-3 times a day Hemodialysis amyloidosis Primary Amyloidosis monitoring of monoclonal protein levels to assess response to treatment is necessary. monitoring of renal function to assess response to treatment. Hemodialysis and Secondary Amyloidosis Monitoring of renal function, underlying disease control and for evaluating the impairment, makes. What are the ways of treatment? Primary Amyloidosis Treatment of the underlying plasma cell disease Melphalan and prednisone are the drugs of choice for the plasma cell disease. Colchicine; It can slow amyloid deposition. Secondary Amyloidosis Underlying inflammatory disease treatment Tacrine, mild to moderate dementia caused by Alzheimer's disease. Familial amyloidosis Colchicine 0.6 mg 2-3 times a day Hemodialysis amyloidosis Primary Amyloidosis monitoring of monoclonal protein levels to assess response to treatment is necessary. monitoring of renal function to assess response to treatment. Hemodialysis and Secondary Amyloidosis Monitoring of renal function, underlying disease control and for evaluating the impairment, makes.